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Very nice trumaine!

I'm back at this. I altered your regex a little (?<=ISA.{97}[01][^\w\s][PT][^\w\s]{2})([^\w\s])(?!\n) The problem I'm having is that it only replaces the first instance of the 106th character. This: ISA*03* *00* *ZZ*000000000 *ZZ*000000000 *130305*1701*|*00501*000001466*0*P*:~GS*HC*000000000*0000000...

By default X12 text is on a single line. I've gotten very good at hitting Ctrl+H, Ctrl+R, Enter, Ctrl+H. However I would like to create a macro to automate this task. I'm not sure where to start, but here's my pseudo code, I appreciate any and all help. // get the character in position 106 << segmen...