It is possible to enable column mode on startup of UltraEdit.
Create a new macro, for example with name EnableColumnMode, with just the macro command ColumnModeOn.
Save this macro without any other macros or together with other macros used often into a .mac macro file, stored for example in the directory %APPDATA%\IDMComp\UltraEdit or even better a subdirectory Macros in this directory. The directory and the name of the macro file do not really matter as it can be seen on next step.
Next configure to automatic load this macro file on startup of UltraEdit and specify EnableColumnMode as macro to execute with 1 set for number of times to execute.
The column mode is enabled automatically on next start of UltraEdit with this configuration.
Let us know the used version of UltraEdit and the used interface mode (ribbon mode, toolbar/menu mode with contemporary menus, toolbar/menu mode with traditional menus) if you need a step by step instruction for this configuration on not finding the appropriate items by yourself.
Best regards from an UC/UE/UES for Windows user from Austria