But you can do what I do since years. Arrange all windows/menu items/ toolbars and set every option like you want. Close UltraEdit. Create a copy of all your uedit32.* files (uedit32.ini, uedit32.kbd, uedit32.mnu, uedit32.tbr in your personal user application folder or in windows directory - see help of UE about INI File ... for details).
Now when you have changed something by mistake, it is no problem anymore. Just close UE and copy or backup files over the current uedit32.* files and everything is restored, except the histories.
Best regards from an UC/UE/UES for Windows user from Austria