Sounds extremly strange. Something is really corrupted on your machine.
First you should update to latest v11 of UltraEdit. I suggest v11.20a for Win9x and v11.20b for Win2k and WinXP. Write an email with your authorization code to IDM support with the request for the installation zip-file you want (localized version?). This update is free for registered v11 users. I can see in readme.txt of v11.20b that there are several crashes of UE v11.00 fixed in next version 11.00a at startup of UE.
Can you start UltraEdit with the shortcut and open the file with the file open dialog or by Drag & Drop? (Test if the installation is OK.)
Can you click on the Windows Start button, select Run and enter the full command line, for example:
"C:\Program Files\IDM Computer Solutions\UltraEdit-32\uedit32.exe" "C:\path to your file\name of your file"
Does this work?
If you previously have had v9.2 maybe the uedit32.ini is the problem. Locate it in the Windows directory and rename all uedit32.* files for example to uedit92.* while no instance of UltraEdit is running. Start UE v11 and it will create a completely new uedit32.ini. This new uedit32.ini is maybe not in the Windows directory anymore. It will be in the hidden directory %APPDATA%\IDMComp\UltraEdit. %APPDATA% is an environment variable which depends on your OS installation. It is something like "C:\Documents and Settings\your windows user name\Application Data".
Open again a file from within the Windows Explorer.
Note: Other UE files at the location of the uedit32.ini are: Advanced.*, Basic.* and uedit32v??.cfg.
If nothing helps, download
Filemon and
Regmon from
SysInternals install both (unpacking the zip-file), run both and capture all disk and registry accesses while you try to open a file with UltraEdit from the Windows Explorer.